周家伟

 浙江工业大学生物工程学院讲师。2020年毕业于首都医科大学天然药物学专业，获得博士学位。研究方向为天然产物生物合成途径解析及合成生物学。在Nature Communication、Metabolic Engineering、New Phytologist、The Plant Journal、International Journal of Biological Macromolecules和Food Microbiology等杂志发表论文15篇。获得授权发明专利10项。

主持、参加的科研项目  

[1] 国家自然基金青年基金项目，82104322，2022/01-2024/12，30万， 主持

[2] 浙江省自然科学基金探索青年基金项目，LQ22H280012，2022/01-2024/12，10万，主持

[3] 北京市教育委员会科技计划重点项目，KZ201710025022，2017/01-2019/12，50万，参加

[4] 国家自然基金面上项目，81773830，2018/01-2021/12，65万，参加

[5] 国家自然基金面上项目，81973418，2020/01-2023/12，63万， 参加

[6] 国家自然基金面上项目，81974515，2020/01-2023/12，63万，参加

一、学术论文：

[1] Jiawei Zhou, Yong Zhang, Tianyuan Hu, Ping Su, Yifeng Zhang, Yujia Liu, Luqi Huang, Wei Gao*. Functional characterization of squalene epoxidase genes in the medicinal plant Tripterygium wilfordii. International Journal of Biological Macromolecules, 2018, 120: 203-212.

[2] Jiawei Zhou, Tianyuan Hu, Linhui Gao, Ping Su, Yifeng Zhang, Yujun Zhao, Shang Chen, Lichan Tu, Yadi Song, Luqi Huang, Wei Gao*. Friedelane-type triterpene cyclase in celastrol biosynthesis from Tripterygium wilfordii and its application for triterpenes biosynthesis in yeast.New Phytologist, 2019, 223 (2): 722-753. 

[3] Jiawei Zhou, Tianyuan Hu, Yuan Liu, Lichan Tu, Yadi Song, Yun Lu, Yifeng  Zhang, Yuru Tong, Yujun Zhao, Ping Su, Xiaoyi Wu, Luqi Huang, Wei Gao*. Cytochrome P450 catalyses the 29-carboxyl group formation of celastrol. Phytochemistry, 2021, 190: 112868.

[4] Jiawei Zhou, Ruini Jiang, Yuan Shi, Weilin Ma, Kaiqiang Liu, Yuele Lu, Linjiang Zhu *, Xiaolong Chen. Sucrose phosphorylase from Lactobacillus reuteri: Characterization and application of enzyme for production of 2-O-α-D-glucopyranosyl glycerol. International Journal of Biological Macromolecules, 2022, 209: 376-384.

[5] Jiawei Zhou, Yuan Shi, Jingyi Fang, Tian Gan, Yuele Lu, Linjiang Zhu*, Xiaolong Chen. Efficient production of α-monoglucosyl hesperidin by cyclodextrin glucanotransferase from Bacillus subtilis. Applied Microbiology and Biotechnology, 2023,107: 4803-4813.

[6] Jiawei Zhou, Jiayan Wang, Yuanlu Zhou, Kaiqiang Liu, Yuele Lu, Linjiang Zhu*, Xiaolong Chen. Microbial community structure and interactions between Aspergillus oryzae and bacteria in traditional solid-state fermentation of Jiangqu. Food Microbiology, 2023, 116: 104346.

[7] Yuan Liu†, Jiawei Zhou†, Panting Liu, Tianyuan Hu, Xuan Liu, Jie Gao, Lin Ma, Yun Lu, Dan Li, Zhouqian Jiang, Xianan Zhang, Luqi Huang, Wei Gao, Xiaoyi Wu, Yifeng Zhang and Changli Liu.  Gene identification and semisynthesis of the anti-inflammatory oleanane-type triterpenoid wilforlide A. New Phytologist, 2023, 241: 1720-1731.

[8] Jiawei Zhou, Yumin Sang, Zhuang Wang, Jiacheng Feng, Linjiang Zhu*, and Xiaolong Chen. Enhancing the enantioselectivity and catalytic efficiency of esterase from Bacillus subtilis for kinetic resolution of l-menthol through semirational design. Journal of Agricultural and Food Chemistry, 2024, 72: 2277-2286.

二、授权发明专利

[1] 雷公藤二萜合酶TwCPS1在制备松香烷型二萜化合物中的应用，CN107058418B.

[2] 雷公藤TwKS与TwCPS3在制备贝壳杉烷型二萜化合物中的应用，CN107058419B.

[3] 雷公藤焦磷酸合酶TwCPS4及其制备松香烷型二萜化合物的应用，CN107058274B.

[4] 雷公藤二萜合酶TwGES1及其编码基因与应用，CN106520745B.

[5] 雷公藤三萜合酶TwOSC1及其编码基因与应用，CN108866030B.

[6] 雷公藤三萜合酶TwOSC3及其编码基因与应用，CN108866029B.

[7] 一种雷公藤原生质体的分离及瞬时转化方法，CN106399223B.

[8] 一种ERG1基因缺陷酵母工程菌、其构建方法及其运用，CN109022299B.

[9] 雷公藤倍半萜合酶TwNES及其编码基因与应用，CN106543289B.

[10]  一种生产次丹参酮二烯的重组酵母工程菌，CN111548946B.

[11] 肉葡萄球菌IEF1018及其应用，CN113151111A.

[12]  Tripterygium wilfordii triterpene synthase TwOSC1, coding gene therefor, and application thereof， PCT 专利，公开号 WO2020/029564A1.

[13] 一种哈茨木霉菌剂稳定剂及其应用，CN113980824B.

[14] 一种对硝基苄基酯酶突变体、编码基因及应用，CN115058406B.

[15]一种从苦豆子中提取分离纯化苦参碱和槐定碱的方法，CN115466256B.

三、科研获奖

[1] 中华中医药学会科学技术奖二等奖（2022）

课程

本科生：发酵工艺综合实验、生化分离工程I

研究生：现代生物分离工程