张静

主要研究方向：

1.核酸药物的递送；

2.功能性水凝胶材料及纳米材料在免疫治疗、药物递送、组织修复等领域的设计与应用；

3.医疗、美容用微针贴片的研究和开发。

简    历：

2004.9~2008.6，武汉大学化学与分子科学学院，材料科学与技术试验班，获得理学学士并保送本校研究生, 导师：张先正教授（长江学者）；

2008.9~2013.6，武汉大学化学与分子科学学院，高分子化学与物理专业，获得理学博士学位，导师：张先正教授（长江学者）；

2013.7至今，浙江工业大学材料学院，副教授；

2016.11~2017.11，美国华盛顿大学，访问学者，合作导师：江绍毅教授。

l  孟阳升（2013级）等，自清洁超疏水涂膜的研究，2016年浙江工业大学新苗人才计划；

l  孟阳升（2013级）等，浙江工业大学第八届新材料应用创新设计大赛一等奖；

l  莫佳颖（2015级）等，抗结冰超疏水隔热车用膜，2018年浙江工业大学大学生创新创业训练计划；

l  何君婷（2015级）等，第一届浙江工业大学“晶通杯”大学生新材料创新创意设计大赛二等奖；

l  莫佳颖（2015级）等，第一届浙江工业大学“晶通杯”大学生新材料创新创意设计大赛三等奖。

l  金露露（2015级）等，Zn掺杂介孔硅制备生物降解的纳米药物载体，2018年浙江工业大学大学生创新创业训练计划。

l  裘浩南（2016级）等，废弃木材的回收及改性制备新型环保玻璃，2019年节能减排社会实践与科技竞赛二等奖。

l  范旭南（2017级）等，第二届浙江工业大学“晶通杯”大学生新材料创新创意设计大赛二等奖。

l  彭湃（2017级）等，第三届浙江工业大学“晶通杯”大学生新材料创新创意设计大赛特等奖。

l  宋烨文（2018级）等，可拉伸、导电、抗污水凝胶的制备及其作为生物传感器的研究，2020年浙江工业大学大学生创新创业训练计划。

l  罗鑫鑫（2018级）等，细菌响应型防污、自清洁的两性离子水凝胶涂层的制备，2021年浙江工业大学大学生创新创业训练计划。

1、国家自然科学基金面上项目：模块化两性离子凝胶构建长效疫苗递送平台的研究，58万

2、浙江省自然科学基金联合项目：细菌触发自防卫、自清洁、长效抗菌凝胶涂层的构建、抗菌机制及应用研究，10万

3、国家自然科学基金青年项目：肿瘤诱导靶向型癌症联合治疗系统的研究，25万

4、浙江省自然科学基金面上项目：肿瘤响应型两性离子多肽序列的设计与应用，8万

5、中国博士后科学基金面上项目：效应金属离子“自增强”双硫仑抗肿瘤疗效的载体的研究，12万

6、企业横向：高效核酸递送技术的开发，50万

7、企业横向：核酸药物体内药效学的开发，45万

8、企业横向：多肽类药物口服固体制剂的开发， 75万

9、企业横向：棕榈酸派利哌酮纳米注射液的体内外相关性研究，10万

10、企业横向：可剥离压敏胶乳液配方及生产工艺的研发，5万

奖励：

1. 王知非，张静，魏芳强，章纪叶，俞图南，宫海波。“用于外科手术培训的3D打印系列模型研发，培训体系建立及推广”，浙江省科技技术进步三等奖。

研究论文：

1.       ShiJie Yu, XiaoDong Xu, Liang Ma, LiDong Cao, JinLei Mao, Hao Chen, Jing Zhang*, ZhiFei Wang*. Emerging frontiers in surgical training: progress in 3D printed gel models. Journal of 3D Printing in Medicine. 2023, 7(3), 3DP013.

2.       Haifeng Ni, Sunxiang Qian, Jie Lu, Jie Feng, Xiao-zhou Mou*, Jing Zhang*. Natural Polysaccharide Delivery Platforms with Multiscale Structure Used for Cancer Chemoimmunotherapy. Molecular Pharmaceutics. 2023, 20 (11), 5778-5789.

3.       Shijie Yu, Haifeng Ni, Xiaodong Xu, Yuqing Cai, Jie Feng, Jing Zhang*. Subcutaneous Rapid Dissolution Microneedle Patch Integrated with CuO2 and Disulfiram for Augmented Antimelanoma Efficacy through Multimodal Synergy of Photothermal Therapy, Chemodynamic Therapy, and Chemotherapy. ACS Biomaterials Science & Engineering. 2023 9 (11), 6425-6437.

4.       Xiaodong Xu, Shijie Yu, Liang Ma, Jinlei Mao, Hao Chen, Zhihao Zhu, Li Wang, Hui Lin, Jing Zhang*, Zhifei Wang*. Multifunctional high-simulation 3D-printed hydrogel model manufacturing engineering for surgical training. International Journal of Bioprinting. 2023, 9(5), 355-368.

5.       Liang Ma, Shijie Yu, Xiaodong Xu, Sidney Moses Amadi, Jing Zhang*, Zhifei Wang*. Application of artificial intelligence in 3D printing physical organ models. Materials Today Bio. 2023, 23,100792.

6.       Jiaji Liu, Minmin Wu, Jie Lu, Qiang He*, Jing Zhang*. Janus intelligent-antibacterial hydrogel dressings for chronic wound healing in diabetes. ACS Applied Polymer Materials. 2023, 5, 2596-2606.

7.       Jing Zhang*, Jie Lu, Sunxiang Qian, Haifeng Ni, Jie Feng*. Injectable zwitterionic cryogels for accurate and sustained chemoimmunotherapy. Journal of Materials Chemistry B. 2023, 11(12): 2733-2744.

8.       Yuqing Cai^#, Xiaodong Xu^#, Minmin Wu, Jiaqi Liu, Jie Feng*, Jing Zhang*. Multifunctional Zwitterionic Microneedle Dressings for Accelerated Healing of Chronic Infected Wound in Diabetic. Biomaterials Science. 2023, 11, 2750-2758.

9.       Jiehong Wang, Kangning Li, Jing Zhang*, Jie Feng*. Transparent and superhydrophobic FHA/SiO2 coatings with obvious anti-soiling performance for photovoltaic modules. Progress in organic coatings. 2023, 183, 107679.

10.    Jing Zhang*, Minmin Wu, Pai Peng, Jiaqi Liu, Jie Lu, Sunxiang Qian, Jie Feng*. “Self-Defensive” Antifouling Zwitterionic Hydrogel Coatings on Polymeric Substrates. ACS Applied Materials & Interfaces. 2022, 14, 56097-56109.

11.    Jing Zhang*, Sunxiang Qian, Lingdong Chen, Minmin Wu, Yuqing Cai, Xiaozhou Mou*, Jie Feng*. Antifouling and antibacterial zwitterionic hydrogels as soft contact lens against ocular bacterial infections[J].European Polymer Journal. 2022, 167: 111037. (SCI)

12.    Jing Zhang*, Lingdong Chen, Liqun Chen, Sunxiang Qian, Xiaozhou Mou*, Jie Feng*. Highly antifouling, biocompatible and tough double network hydrogel based on carboxybetaine-type zwitterionic polymer and alginate. Carbohydrate Polymers. 2021, 257, 117627. (SCI)

13.    Jing Zhang, Pai Peng, Lingdong Chen, Liping Zhao*, Jie Feng*. Antifouling poly(N-(2-hydroxyethyl)acrylamide)/sodium alginate double network hydrogels with eminent mechanical properties. Polymer Testing. 2021, 95, 107087. (SCI)

14.    Jing Zhang*, Sunxiang Qian, Lingdong Chen, Liqun Chen, Liping Zhao*, Jie Feng*. Highly antifouling double network hydrogel based on poly(sulfobetaine methacrylate) and sodium alginate with great toughness. Journal of Materials Science & Technology. 2021, 85, 235. (SCI)

15.    Jian Lv, Chenxi Zhu, Haonan Qiu, Jing Zhang*, Changdong Gu, and Jie Feng*. Robust icephobic epoxy coating using maleic anhydride as a crosslinking agent. Progress in organic coatings. 2020, 142, 105561. (SCI)

16.    Jing Zhang*, Lingdong Chen, Biao Shen, Yirou Wang, Feiyu Tang, and Jie Feng*. Highly transparent, self-healing, injectable and self-adhesive chitosan/polyzwitterion-based double network hydrogel for potential 3D printing wearable strain sensor. Materials Science & Engineering C. 2020, 117, 111298. (SCI)

17.    Jing Zhang*, Lingdong Chen, Biao Shen, Jiaying Mo, Feiyu Tang, and Jie Feng*. Highly stretchable and self-healing double network hydrogel based on polysaccharide and polyzwitterion for wearable electric skin. Polymer. 2020, 194, 122381. (SCI)

18.    Xiangwei Kong, Chenxi Zhu, Jian Lv, Jing Zhang*, and Jie Feng*. Robust fluorine-free superhydrophobic coating on polyester fabrics by spraying commercial adhesive and hydrophobic fumed SiO₂ nanoparticles. Progress in organic coatings. 2020, 138, 105342. (SCI)

19.    Jing Zhang*, Lingdong Chen, Biao Shen, Liqun Chen, and Jie Feng*. Ultra-high strength poly(N-(2-hydroxyethyl)acrylamide)/chitosan hydrogel with repelling and killing bacteria property. Carbohydrate Polymers. 2019, 225, UNSP 115160. (SCI)

20.    Jing Zhang*, Biao Shen, Lingdong Chen, Liqun Chen, Jiaying Mo, and Jie Feng*. Antibacterial and Antifouling Hybrid Ionic-Covalent Hydrogels with Tunable Mechanical Properties. ACS Applied Materials & Interfaces. 2019, 11, 31594-31604. (SCI)

21.    Chenxi Zhu, Weiqiang Lin, Lingdong Chen, Jian Lv, Jing Zhang*, and Jie Feng*. Deep color, heat-reflective, superhydrophobic and anti-soiling coatings with Check for waterborne silicone emulsion. Solar Energy Materials and Solar Cells.2019, 199, 129-135. (SCI)

22.    Jing Zhang*, Liqun Chen, Biao Shen, Lingdong Chen, Jiaying Mo, and Jie Feng*. Dual-sensitive graphene oxide loaded with proapoptotic peptides and anticancer drugs for cancer synergetic therapy. Langmuir. 2019, 35, 6120-6128. (SCI)

23.    Jing Zhang*, Biao Shen, Liqun Chen, Lingdong Chen, Yangsheng Meng, and Jie Feng*. A dual-sensitive mesoporous silica nanoparticle based drug carrier for cancer synergetic therapy. Colloids and Surfaces B-Biointerfaces. 2019, 175, 65-72. (SCI)

24.    Jing Zhang*, Liqun Chen, Jiada Chen, Quan Zhang, and Jie Feng*. Stability, cellular uptake, and in vivo tracking of zwitterion modified graphene oxide as a drug carrier. Langmuir. 2019, 35, 1495-1502. (SCI)

25.    Jing Zhang*, Chenxi Zhu, Jian Lv, Weicheng Zhang, and Jie Feng*. Preparation of colorful, infrared-reflective, and superhydrophobic polymer films with obvious resistance to dust deposition. ACS Applied Materials & Interfaces. 2018, 10, 40219-40227. (SCI)

26.    Jing Zhang*, Jiada Chen, Zhefan Yuan, and Jie Feng*. Zwitterionic coating promotes zinc oxide quantum dot stability and reduces aggregation in biological media. Journal of Nanoscience and Nanotechnology. 2018, 18, 7713-7720. (SCI)

27.    Jing Zhang*, Weicheng Zhang, Junjie Lu, Chenxi Zhu, Weiqiang Lin, and Jie Feng*. Aqueous epoxy-based superhydrophobic coatings: Fabrication and stability in water. Progress in Organic Coatings. 2018, 121, 201-208. (SCI)

28.    Xiangwei Kong, Jing Zhang*, Qi Xuan, Junjie Lu, and Jie Feng*. Superhydrophobic coating for antifouling of chinese paintings. Langmuir. 2018, 34, 8294-8301. (SCI)

29.    Jing Zhang*, Weiqiang Lin, Chenxi Zhu, Jian Lv, Weicheng Zhang and Jie Feng*. Dark, infrared reflective, and superhydrophobic coatings by waterborne resins. Langmuir. 2018, 34, 5600-5605. (SCI)

30.    Jing Zhang*, Liqun Chen, Jiada Chen, Dan Wu, and Jie Feng*. Dextran microgels loaded with ZnO QDs: pH-triggered degradation under acidic conditions. Journal of Applied Polymer Science. 2018, 135, 45831. (SCI)

31.    Jing Zhang*, Mengfei Li, Zhefan Yuan, Dan Wu, Jiada Chen, and Jie Feng*. Stepwise-activable multifunctional peptide-guided prodrug micelles for cancerous cells intracellular drug release. Journal of Nanoparticle Research.2016, 18, 299. (SCI)

32.    Jing Zhang*, Dan Wu, and Jie Feng*. One-step way to form prodrug micelles with high amount drug loading. Journal of Nanoscience and Nanotechnology.2016, 16, 5586-5591. (SCI)

33.    Jing Zhang*, Dan Wu, Mengfei Li, and Jie Feng*. Multifunctional mesoporous silica nanoparticles based on charge-reversal plug-gate nanovalves and acid-decomposable ZnO quantum dots for intracellular drug delivery. ACS Applied Materials & Interfaces.2015, 7, 26666-26673. (SCI)

34.    Jing Zhang, Zhefan Yuan, Ya Wang, Weihai Chen, Guofeng luo, Sixue Cheng, Renxi Zhuo and Xianzheng Zhang*. Multifunctional envelope-type mesoporous silica nanoparticles for tumor-triggered targeting drug delivery. Journal of the American Chemical Society. 2013, 135, 5068-5073. (SCI)

35.    Ya Wang, Jing Zhang, Huizhen Jia, Juan Yang, Siyong Qin, Chenwei Liu, Renxi Zhuo and Xianzheng Zhang*. Design of a cellular-uptake-shielding magnetic catcher for cancer cell separation. Macromolecular Bioscience. 2012, 12, 1321-1325. (SCI)

36.    Jing Zhang, Xiaoding Xu, Yun Liu, Chenwei Liu, Xiuhong Chen, Cao Li, Renxi Zhuo and Xianzheng Zhang*. Design of an “active defense” system as drug carriers for cancer therapy. Advanced Functional Materials. 2012, 22, 1704-1710. (SCI)

37.    Jing Zhang, Cao Li, Zhiyuan Xue, Haiwei Cheng, Fuwei Huang, Renxi Zhuo and Xianzheng Zhang*. Fabrication of lactobionic-loaded chitosan microcapsules as potential drug carriers targeting the liver. Acta Biomaterialia. 2011, 7, 1665-1673. (SCI)

38.    Jing Zhang, Cao Li, Ya Wang, Renxi Zhuo and Xianzheng Zhang*. Controllable exploding microcapsules as drug carriers. Chemical Communications. 2011, 47, 4457. (SCI)

39.    Jing Zhang, Xiaoding Xu, Dequn Wu, Xianzheng Zhang*, and Renxi Zhuo. Synthesis of thermosensitive P(NIPAAm-co-HEMA)/cellulose hydrogels via “click” chemistry. Carbohydrate Polymers. 2009, 77, 583-589. (SCI)

授权发明专利：

1.      张静，李猛飞，冯杰. 一种还原敏感型多肽前药纳米胶束的制备方法，专利号：ZL 201511019616.8。

2.      张静，吴丹. 以带电无机纳米粒子为交联点的复合微凝胶的制备方法，专利号：ZL 201610082223.6。

3.      张静，陈佳达. 生物基稳定的石墨烯衍生物及其制备方法与应用，专利号：ZL 201610889802.1。

4.      张静，沈彪. 一种生物介质稳定的双敏感型的癌症联合治疗系统及构建方法，专利号：ZL 201810285002.8。

5.      张静，陈丽群. 一种用于癌症治疗的高稳定性的联合给药体系及构建方法，专利号：ZL 201810283686.8。

6.      张静，陈丽群，冯杰.一种强韧抗污双网络水凝胶及其制备方法，专利号：ZL 201910198625.6。

7.      张静，冯杰，沈彪.一种壳聚糖/聚磺基甜菜碱双网络自愈合水凝胶及其制备方法，专利号：ZL 201910576595.8。

8.      张静，冯杰，陈凌东. 一种壳聚糖/两性离子与丙烯酸共聚物双网络自愈合水凝胶及其制备方法，专利号：ZL 201910576594.3。

9.      张静，冯杰，钱隼翔. 一种高强度可降解的抗菌水凝胶及其制备方法，专利号：ZL 202010832495.X。

10.   张静，冯杰，陈凌东。一种抗溶胀抗黏附水凝胶及其制备方法、应用，专利号：ZL 202011592073.6。

11.   张静，陈凌东。一种载药抗黏附隐形眼镜水凝胶材料及制备方法，专利号：ZL 202011595403.7。

12.   张静，吴敏敏，彭湃，罗鑫鑫。一种具有细菌响应性防污的两性离子水凝胶涂层及其制备方法，专利号：ZL 202110734483.8。

13.   张静，陆杰。一种两性离子凝胶海绵及其制备方法，专利号：ZL 202111548516.6。