杨根生

杨根生，教授，博士生导师，药学院药剂所所长。

主要研究领域：

• 纳米靶向药物递送系统

• 经皮给药新剂型

• 3D打印制剂新工艺新技术

累计主持科研项目20余项，发表高水平学术论文100余篇，申请并授权发明专利数十项，累计指导硕士、博士研究生近100人。

• 承担《细胞分子生物学》、《制剂工程》、《高等药剂学》和《递药系统新进展》等课程主讲工作

• 累计指导研究生近100人

  
  

• 分别于2006和2018获评“浙江工业大学我最喜爱老师”荣誉称号

• 多次指导研究生获得“校优秀毕业论文”、“校优秀毕业生”和国家奖学金等荣誉

主持和参与科研项目

1. 国家自然科学基金委员会，面上项目，22078297，靶点特异性程序化响应生物分子马达递送系统构建及机制研究，2021-01至2024-12，63万元，在研，主持

2. 国家自然科学基金委员会，面上项目，21376223，参与酶切肽肿瘤特异性改性脂质体与聚环酯增载亲脂药物控释纳米粒的制备及性能研究，2013-01至2017-12，80万元，结题，主持

3. 浙江省自然科学基金委员会，一般项目，LY19B060012，多药共给的智能酶响应杂化纳米粒联合抗肿瘤治疗给药体系研究，2019-01至2021-12，10万元，在研，主持

4. 企业横向，KYY-HX-20200670，药物纳米递送系统的开发，2020-08至2024-07，100万元，在研，主持

5. 企业横向，KYY-HX-20210466，氨碘肽滴眼液药效学深度研究与技术开发，2021-04至2022-04，15万元，在研，主持

6. 青海省科技合作专项，2017-HZ-814，槲皮素-月桂酸共轭物纳米胶束的制备及提高生物利用度的研究，2017-09至2019-12，8万元，结题，主持

7. 企业横向，KYY-HX-20200670，药物纳米递送系统的开发，2020-08至2024-07，100万元，在研，主持

8. 国家自然科学基金委员会，青年项目，51803181，肿瘤乏氧微环境靶向细菌递药微机器人的构建及其抗结肠癌作用研究，2019-01至2021-12，25万元，在研，参与

9. 国家自然科学基金委员会，青年项目，21808216，多尺度下超细粉静电沉积构建渗透泵包衣膜机制研究，2019-01至2021-12，21万元，在研，参与

10. 浙江省自然科学基金委员会，一般项目，LY20H300006，光“触发式”智能释药纳米载体用于肿瘤深层递药研究，2020-01至2022-12，9万元，在研，参加

11. 浙江省自然科学基金，一般项目，LY20B060007，3D打印仿生微流控经皮递药系统研究，2020.01至2022.12，9万元，在研，参与

12. 企业横向，干粉吸入制剂药效学研究与技术开发，2021.03-2023.12，200万元，在研，参与

13. 企业横向，KYY-HX-20210858，基于蛋白冠的靶向纳米递送系统的开发，2021-09至2025-09，100万元，在研，参加

• 发表学术论文100余篇，部分列举如下

[1] Fangyuan Guo; Nan Yu; Yunlong Jiao; Weiyong Hong; Kang Zhou; Xugang Ji; Huixing Yuan; Haiying Wang; Aiqin Li; Guoping Wang; Gensheng Yang*; Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer, Drug Delivery, 2021, 28(1):1709-1721.

[2] Fangyuan Guo; Qiafan Fu; Kang Zhou; Chenghao Jin; Wenchao Wu; Xugang Ji; Qinying Yan; Qingliang Yang; Danjun Wu; Aiqin Li; Gensheng Yang*; Matrix metalloprotein-triggered, cell penetrating peptide-modified star-shaped nanoparticles for tumor targeting and cancer therapy, Journal of Nanobiotechnology, 2020, 18: 48. 

[3] Guo, Fangyuan; Fu, Qiafan; Jin, Chenhao; Ji, Xugang; Yan, Qinying; Yang, Qingliang; Wu, Danjun; Gao, Ying; Hong, Weiyong; Li, Aiqin; Yang, Gensheng*; Dual functional matrix metalloproteinase-responsive curcumin-loaded nanoparticles for tumor-targeted treatment , Drug Delivery, 2019, 26(1):1027-1038.

[4] Weiyong Hong; Ying Gao; Bang Lou; Sanjun Ying; Wenchao Wu; Xugang Ji; Nan Yu; Yunlong Jiao; Haiying Wang; Xuefeng Zhou; Anqin Li; Fangyuan Guo*; Gensheng Yang*; Curcumin-Loaded Hybrid Nanoparticles: Microchannel-Based Preparation and Antitumor Activity in a Mouse Model, International Journal of Nanomedicine, 2021, 16: 4147-4159 

[5] Weiyong Hong*; Fangyuan Guo*; Nan Yu; Sanjun Ying; Bang Lou; Jiangqing Wu; Ying Gao; Xugang Ji; Haiying Wang; Aiqin Li; Guoping Wang; Gensheng Yang; A Novel Folic Acid Receptor-Targeted Drug Delivery System Based on Curcumin-Loaded β-Cyclodextrin Nanoparticles for Cancer Treatment, Drug Design, Development and Therapy, 2021, 15: 2843–2855 

[6]cFangyuan Guo, Wei Zhang, Xiaohong Pei, Xia Shen, Qinying Yan, Weiyong Hong, Gensheng Yang. PEGylated self-assembled enzyme-responsive nanoparticles for effective targeted therapy against lung tumors[J]. Journal of Nanobiotechnology. 2018, 16: 57. 

[7] Fangyuan Guo, Dongxue Huang, Wei Zhang, Qinying Yan, Qingliang Yang, Yan Yang, Hanbing Li, Junxian Yun, Weiyong Hong, Gensheng Yang. Star-shaped polyester-based elastomers as an implantable delivery system for insulin: Development, pharmacokinetics, pharmacodynamics, and biocompatibility[J]. Materials Sience and Engineering C. 2018, 84, 180-187. 

[8] Guo fangyuan, Dingjia Guo, Wei Zhang, Minli Yao, Junxian Yun, Gensheng Yang. Preparation of curcumin-loaded PCL-PEG-PCL triblock copolymeric nanoparticles by a microchannel technology, European Journal of Pharmaceutical Sciences, 2017, 99: 328-336. 

[9] Fangyuan Guo, Wei Zhang, Xiaohong Pei, Xia Shen, Qinying Yan, Hanbing Li, Junxian Yun, Gensheng Yang. Biodegradable star-shaped polycyclic ester elastomers: preparation, degradability, protein release, and biocompatibility in vitro[J]. Journal of Bioactive and Compatible Polymers. 2017, 32(2): 178-195.

[10] Fangyuan Guo, Wei Zhang, Xiaohong Pei, Xia Shen, Qinying Yan, Weiyong Hong, Gensheng Yang. Synthesis, characterization and cytotoxicity of star-shaped polyester-based elastomers as a controlled release system for protein[J]. Journal of Applied Polymer Science. 2016, 133(18), DOI: 10.1002/app.43393 

[11] Qingliang Yang, Feng Yuan, Jiale Chen, Hang Zhou, Gensheng Yang*, Jesse Zhu^*., Delayed sustained drug release from electrostatic powder coated tablets with ultrafine polymer blends. Powder Technology, 2021, 394, 496-503. doi.org/10.1016/j.powtec.2021.08.088

[12] Lei Xu, Qingliang Yang *, Wei Qiang, Huijie Li, Weizhen Zhong, Siying Pan, Gensheng Yang *, Hydrophilic excipient-independent drug release from SLA-printed pellets, Pharmaceutics, 2021, 13, 1717.

[13] Qingliang Yang, Ying Gao, Lei Xu, Weiyong Hong, Yuanbin She, Gensheng Yang*. Enzyme-driven micro/nanomotors: Recent advances and biomedical applications, International Journal of Biological Macromolecules. 2021,167: 457-469. doi.org/10.1016/j.ijbiomac.2020.11.215

[14] Qingliang Yang, Weizhen Zhong, Lei Xu, Huijie Li, Qinying Yan, Yuanbin She, Gensheng Yang*. Recent progress of 3D-printed microneedles for transdermal drug delivery, International Journal of Pharmaceutics, 2021, 593,120106. doi.org/10.1016/j.ijpharm.2020.120106

[15] Qingliang Yang, Lei Xu, Weizhen Zhong, Yan Yang, Kaiqi Shi, Gensheng Yang^*. Recent Advances in Motion Control of Micro/Nanomotors. Advanced Intelligent Systems, 2020, 2(8), 2000049. doi.org/10.1002/aisy.202000049

[16] Qingliang Yang, Feng Yuan, Lei Xu, Weizhen Zhong, Yan Yang, Kaiqi Shi, Gensheng Yang^*, Jesse Zhu^*., Moisture barrier films for herbal medicines fabricated by electrostatic dry coating with ultrafine powders. Powder Technology, 2020, 366, 701-708. doi.org/10.1016/j.powtec.2020.03.023

[17] Qingliang Yang, Feng Yuan, Lei Xu, Qinying Yan, Yan Yang, Danjun Wu, Fangyuan Guo, Gensheng Yang^*. An update of moisture barrier coating for drug delivery, Pharmaceutics, 2019, 11(9), 436. doi:10.3390/pharmaceutics11090436

[18] D. Wu, S. Xu, X. Zhang, Y. Li, W. Zhang, Q. Yan, Q. Yang, F. Guo, G. Yang^*. A near-infrared laser-triggered size-shrinkable nanosystem with in situ drug release for deep tumor penetration. ACS Applied Materials & Interfaces, 2021,13，16036−16047.

[19] D. Wu, Y. Li, L. Zhu, W. Zhang, S. Xu, Y. Yang, Q. Yan, G. Yang^*. A biocompatible superparamagnetic chitosan-based nanoplatform enabling targeted SN-38 delivery for colorectal cancer therapy. Carbohydrate Polymers, 2021, 274, 118641. 

[20] D. Wu, L. Zhu, Y. Li, X. Zhang, S. Xu, G. Yang^*, T. Delair^*. Chitosan-based colloidal polyelectrolyte complexes for drug delivery: a review. Carbohydrate Polymers, 2020, 238, 116126. 

[21]  D. Wu, L. Zhu, Y. Li, H. Wang, S. Xu, X. Zhang, R. Wu, G. Yang^*. Superparamagnetic chitosan nanocomplexes for colorectal tumor-targeted delivery of irinotecan. International Journal of Pharmaceutics, 2020, 584, 119394. 

[22] Yan, QY, Weng, JQ, Wu, XQ, Wang, WW, Yang, QL, Guo, FY, Wu, DJ, Song, Y, Chen, F, Yang, GS. Characteristics, Cryoprotection Evaluation and In Vitro Release of BSA-Loaded Chitosan Nanoparticles, MARINE DRUGS, 2020, 18(6): 315

[23] Yan, QY, Wang, WW, Weng, JQ, Zhang, ZH, Yin, LN, Yang, QL, Guo, FY, Wang, XG, Chen, F, Yang, GS. Dissolving microneedles for transdermal delivery of huperzine A for the treatment of Alzheimer's disease, DRUG DELIVERY, 2020, 27(1): 1147-1155

[24] Wu, WC, Wu, JQ, Fu, QF, Jin, CH, Guo, FY, Yan, QY, Yang, QL, Wu, DJ, Yang, Y, Yang, GS. Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14: 4683-4695

• 申请并授权发明专利数十项

[1] 郭钫元，严琴英，郭定佳，洪伟勇，杨根生. 一种姜黄素脂质纳米粒悬浮液或纳米粒的制备方法，中国专利，ZL 2013 1 0723889.1

[2] 杨根生，郭钫元，蔡为明，洪伟勇. 一种头孢地嗪酸侧链中间体的合成方法, 中国专利, ZL 2011 1 0338870.6 2015

[3] 郭钫元，杨根生，严琴英，洪伟勇. 一种硫酸头孢喹肟的制备方法，中国专利，ZL 2014 1 0209739.3

[4] 杨根生，郭钫元，张玮，贠军贤. 一种聚环酯弹性体的制备方法. 中国专利，ZL 2015 1 0248785.9

[5] 杨根生; 金成浩; 郭钫元; 马玉花; 一种通过十二酰氯修饰的槲皮素衍生物及其合成方法, 2021-04-09, 中国, ZL201910314568.3.

[6] 杨根生; 金成浩; 郭钫元; 马玉花; 一种槲皮素衍生物及其制备方法, 2021-06-22, 中国, ZL201910315123.7.

[7] 郭钫元; 杨根生; 吴文超; 吴江青; 黄冬雪; 张逸菲; 一种具有酶靶向性的星状给药纳米粒的制备, 2020-06-30, 中国, ZL201710694178.4.

[8] 杨根生; 郭钫元;黄冬雪; 一种聚己内酯-环糊精给药纳米粒的制备方法, 2020-04-24, 中国, ZL201710436906.1.

[9] 郭钫元; 杨根生; 黄冬雪; 袁怡琦; 韩宁; 周雨青; 朱珊; 洪伟勇; 一种聚四己内酯-季戊四醇给药纳米粒的制备方法, 2020-04-24, 中国, ZL201710436911.2.

[10] 郭钫元; 杨根生; 黄冬雪; 张逸菲; 一种酶敏感性两亲性聚酯MePEG-Peptide-PER-CL给药纳米粒的制备方法, 2020-04-07, 中国, ZL201710694241.4.

[11] 郭钫元; 杨根生; 贠军贤; 洪伟勇; 一种聚三己内酯-丙三酸给药纳米粒的微通道制备方法, 2020-02-21, 中国, ZL201710436916.5.

• 编写专著：

[1] 杨根生, 欧志敏, 郭钫元. 《生物药物合成学》，浙江大学出版社，2012

杨根生课题组成员

• 杨根生

• 王文喜

• 杨燕

• 严琴英

• 杨庆良

• 吴丹君

• 郭钫元