Yajun Wang

Yajun Wang, Ph.D., Professor, Doctoral supervisor, chief scientist of the National Key Research and Development Program, and Jianxing Distinguished Professor of Zhejiang University of Technology. He is currently the Dean of the School of Pharmaceutical Sciences, Zhejiang University of Technology (ZJUT), the Executive Director of the Collaborative Innovation Center for Green Pharmaceutical, member of the Molecular Microbiology and Bioengineering Professional Committee of the Chinese Society of Microbiology, and member of the Enzyme Engineering Professional Committee of the Chinese Society of Microbiology.

Professor Wang undertakes 1 National Key R&D Program, 3 CNSF fundings, 1 sub-project of the National Key R&D Program, 1 key project of the Natural Science Foundation of Zhejiang Province, and 3 fundings entrusted by enterprises. He has over 100 publications, including ACS Catalysis, Chemical Engineering Journal, Chemical Engineering Science, Biotechnology & Bioengineering, Biotechnology Journal, et al. He has 27 issued Chinese Invention Patents. He has received 1 science and technology award, and 6 provincial and ministerial science and technology awards.

Welcome young scholars having backgrounds in Biopharmaceutical, Pharmacy, Biology, Organic Chemistry (Synthesis), Enzyme Engineering, Synthetic Biology, Artificial Intelligence, Microbial Engineering and related majors to join our group.

Adress: Room 533, Building 1 of the Collaborative Innovation Center, Moganshan Campus, Zhejiang University of Technology

Email：wangyj@zjut.edu.cn

WeChat: zjutwyj

1.   Dai, C,. Tian, J. X., Chen, Y. F., Ni, Y. H., Cui, L., Cao, H. X., Song, L. L., Xu, S. Y., Wang, Y. J.,* Zheng, Y. G. Computer-aided design to enhance the stability of aldo-keto reductase KdAKR. Biotechnology Journal, 2024, DOI:10.1002/biot.202300637.

2.   Xu, S. Y., Chu, R. L., Liu, H. T., Weng, C. Y., Wang, Y. J.,* Zheng, Y. G. Computer-directed rational design enhanced the thermostability of carbonyl reductase LsCR for the synthesis of ticagrelor precursor. Biotechnology and Bioengineering, 2024, DOI:10.1002/bit.28662.

3.   Xu, S. Y., Zhou, L., Xu, Y., Hong, H. Y., Dai, C., Wang, Y. J.*, Zheng, Y. G. Recent advances in structure-based enzyme engineering for functional reconstruction. Biotechnology and Bioengineering, 2023, 120 (12): 3427-3445. doi.org/10.1002/bit.28540.

4.   Dai, C., Cao, H. X., Tian, J. X., Gao, Y. C., Liu, H. T., Xu, S. Y., Wang, Y. J.*, Zheng, Y. G. Structural-guided design to improve the catalytic performance of aldo-keto reductase KdAKR. Biotechnology and Bioengineering, 2023, 120 (12): 3543-3556. doi.org/10.1002/bit.28535.

5.   Liu, H. T., Weng, C. Y., Zhou, L., Xu, H. B., Liao, Z. Y., Hong, H. Y., Ye, Y. F., Li, S. F., Wang, Y. J.*, Zheng, Y. G. Co-evolving stability and activity of LsCR by a single point mutation and constructing neat substrate bioreaction system. Biotechnology and Bioengineering, 2023, 120(6): 1521-1530. DOI: 10.1002/bit.28357.

6.   Cheng F., Zhou, S. Y., Chen, L. X., Zhang, W., Li, S. F., Weng, C. Y., Wang, Y. J.*, Zheng, Y. G. Reaction-kinetic model-guided biocatalyst engineering for dual-enzyme catalyzed bioreaction system. Chemical Engineering Journal, 2023, 452: 138997. doi.org/10.1016/j.cej.2022.138997.

7.   Li, S. F., Cheng, F., Wang, Y. J.*, Zheng, Y. G. Strategies for tailoring pH performances of glycoside hydrolases. Critical Reviews in Biotechnology, 2023, 43 (1): 121-141. doi: 10.1080/07388551.2021.2004084.

8.   Zhang, W., Li, S. F., Zhu, J. Q., Cao, H.X., Liu, H. T., Shao, Z. Q., Xu, S. Y., Wang, Y. J.,* Zheng, Y. G. Constructing a continuous-flow bioreactor with co-immobilized KmAKR and BmGDH for synthesizing tert-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate. Biochemical Engineering Journal, 2023, 197: 108964. https://doi.org/10.1016/j.bej.2023.108964.

9.   Qiu, S., Xu, S. Y., Wang, Y. J.*, Zheng, Y. G. Chemoenzymatic catalysis of tert-butyl 6-cyano-(3R,5R)-dihydroxyhexanoate by aldo-keto reductase coupled with composite Fe₃O₄ nanozyme scaffold. Chemical Engineering Science, 2022, 261: 117935. doi.org/10.1016/j.ces.2022.117935.

10.Weng, C. Y., Gao, X. F. Chu, R. L., Xie, W. B., Wang, Y. J.*, Zheng, Y. G. Protein engineering of carbonyl reductases for asymmetric synthesis of ticagrelor precursor (S)-2-chloro-1-(3,4-difluorophenyl)ethanol. Biochemical Engineering Journal, 2022, 108600. doi.org/10.1016/j.bej.2022.108600.

11.Liu, H.T., Weng, C. Y., Xu, S. Y., Li, S. F., Wang, Y. J.*, Zheng, Y. G. Directed evolution of a carbonyl reductase LsCR for the enantioselective synthesis of (1S)-2-Chloro-1-(3,4-difluorophenyl) ethanol. Bioorganic Chemistry, 2022, 127: 105991. doi.org/10.1016/j.bioorg.2022.105991.

12.Cheng, F., Xie, W. B., Gao, X. F., Chu, R. L., Xu, S. Y., Wang, Y. J.*, Zheng, Y. G. Development of a new chemo-enzymatic catalytic route for synthesis of (S)-2-chlorophenylglycine. Journal of Biotechnology, 2022, 358: 17-24. doi.org/10.1016/j.jbiotec.2022.08.013.

13.Li, S. F., Xu, S.Y., Wang, Y. J.*, Zheng, Y. G. Tailoring pullulanase PulAR from Anoxybacillus sp. AR-29 for enhanced catalytic performance by a structure-guided consensus approach. Bioresources and Bioprocessing, 2022, 9: 25.

14.Pan, Z. T., Liu, T., Ma, Y. M., Yan, J. B., Wang, Y. J.*. Construction of quinazolin(thi)ones by brønsted acid/visible-light photoredox relay catalysis. Chinese Journal of Chemistry, 2022, 42 (9): 2823-2831. doi: 10.6023/cjoc202206001.

15.Cheng F., Chen Y., Qiu S., Zhai Q. Y., Liu, H. T., Li, S. F., Weng, C. Y., Wang, Y. J.*, Zheng, Y. G. Controlling stereopreference of carbonyl reductases for enantioselective synthesis of atorvastatin precursor. ACS Catalysis, 2021, 11 (5): 2572–2582. doi.org/10.1021/acscatal.0c05607.

16.Cheng, F., Zhai, Q. Y., Gao, X. F., Liu, H. T., Qiu, S., Wang, Y. J.*, Zheng, Y. G. Tuning enzymatic properties by protein engineering toward catalytic residues in carbonyl reductase. Biotechnology and Bioengineering, 2021, 118(12): 4643-4654. doi: 10.1002/bit.27925.

17.Li, S. F., Xie, J. Y., Qiu, S., Xu, S. Y., Cheng, F., Wang, Y. J.*, Zheng, Y. G. Semi-rational engineering of an aldo-keto reductase KmAKR for overcoming trade-offs between catalytic activity and thermostability. Biotechnology and Bioengineering, 2021, 118 (11): 4441-4452. DOI: 10.1002/bit.27913.

18.Qiu, S., Xu, S. Y., Li, S. F., Meng, K. M., Chen, F., Wang, Y. J.*, Zheng, Y. G. Fluorescence-based screening for engineered aldo-keto reductase KmAKR with extended substrate scope and improved catalytic performance. Biotechnology Journal, 2021, 16 (9): 2100130. DOI:10.1002/biot.202100130.

19.Weng, C. Y., Wang, C. E., Xie, W. B., Xu, S. Y., Wang, Y. J.*, Zheng, Y. G. Comparative proteome analysis of Actinoplanes utahensis grown on various saccharides based on 2D-DIGE and MALDI-TOF/TOF-MS. Journal of Proteomics, 2021, 239: 104193. doi.org/10.1016/j.jprot.2021.104193.

20.Li, S. F., Xie, J. Y., Qiu, S., Zhou, S. Y., Wang, Y. J.*, Zheng, Y. G. Tailoring an aldo-keto reductase KmAKR for robust thermostability and catalytic efficiency by stepwise evolution and structure-guided consensus engineering. Bioorganic Chemistry, 2021, 109: 104712. doi.org/10.1016/j.bioorg.2021.104712.

21.Weng, C. Y., Wang, D. N., Ban, S. Y., Zhai, Q. Y. Hu, X. Y., Cheng, F., Wang, Y. J.*, Zheng, Y. G. One-step eantioselective bioresolution for (S)-2-chlorophenylglycine methyl ester catalyzed by the immobilized Protease 6SD on multi-walled carbon nanotubes in a triphasic system. Journal of Biotechnology, 2021, 325: 294-302. doi.org/10.1016/j.jbiotec.2020.10.007.