Tong shengqiang

Positions:

2016.12 - present       Professor

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

2011.12 - 2016.11       Associate professor

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

2013.8 - 2014.9      Visiting scholar

National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, Bethesda, Maryland, USA

2006.6 - 2011.11        Lecturer

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

2004.6 - 2006.11        Teaching Assistant

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

Education:

2007.9-2011.6    Ph.D. in Biochemical Engineering

Zhejiang University, Hangzhou, China

2001.9-2004.6    M.S. in Biochemical Engineering

Zhejiang University of Technology, Hangzhou, China

1996.9-2000.6    B.S. in Chemical Engineering

Zhejiang University of Technology, Hangzhou, China

2004.9-2013.8 Chemical pharmaceutical technology

2014.9-2021.8 Chemical pharmaceutical technology

2018.9-present Scientific Writing

2018.9-present Modern Instrumental Analysis

2020-present publications:

1. Haiping Xiang, Ping Xu, Weiyi Wen, Huiyun Qiu, Chu Chu*, Qingsong Shao*, Shengqiang Tong*. Screening, characterization of trace α-glucosidase inhibitors from the root of Pueraria lobata and evaluation of their hypoglycemic activity. Food Bioscience, 2023, 53: 102641. Available online 11 April 2023, 102641.https://doi.org/10.1016/j.fbio.2023.102641

2.  Mengyi Wen, Sihua Quan, Huiyun Qiu, Weiyi Wen, Ben Chen, Yuxia Chen*, Jianyun Peng*, Shengqiang Tong*. High-resolution monophenolase/diphenolase/radical scavenging profiling for rapid screening of natural whitening candidates from Rosa rugosa cv. ‘Plena’. Journal of Separation Science, 2023, 2200987. First published: 07 April 2023 https://doi.org/10.1002/jssc.202200987

3. Liqun Fang, Tingting Lin, Ben Chen, Haibo You, Chunyan Wu, Chu Chu, Shengqiang Tong*. HPLC micro-fraction bioactive evaluation combined with countercurrent chromatographic separation of antioxidants from Citrus peel and their tyrosinase inhibition activities. Journal of Separation Science,  2023, 46(4), 2200764.  https://doi.org/10.1002/jssc.202200764

4. Wenyu Sun, Huiyun Qiu, Haibo You, Ben Chen, Liqun Fang, Junqing Qian, Shengqiang Tong*. Degree and distribution of substitution of hydroxypropyl-β-cyclodextrin in enantioselective liquid-liquid extraction and countercurrent chromatographic enantioseparation. Journal of Chromatography A, 2023, 1687, 463684. https://authors.elsevier.com/sd/article/S0021-9673(22)00875-5.

5. Weiyi Wen, Ping Xu, Haiping Xiang, Mengyi Wen, Xuemin Ye, Chu Chu*, Shengqiang Tong*. Comprehensive two-dimensional countercurrent chromatography × gas chromatography characterization of Artemisia argyi essential oil, Analytica Chimica Acta, 2023, 1237, 340614. https://authors.elsevier.com/sd/article/S0003-2670(22)01185-0.

6.  Haibo You, Ben Chen, Liqun Fang, Tingting Lin, Ping Xu, Chu Chu, Shengqiang Tong*. Analytical enantioseparation of N-alkyl drugs by reversed phase liquid chromatography with carboxymethyl-β-Cyclodextrin as mobile phase additive. Chirality, 2023, 35(1), 58-66.   http://doi.org/10.1002/chir.23516.

7. Xiaoyuan Lv, Haibo You,Huiyun Qiu, Mengyi Wen,Chuncui Zheng, Shengqiang Tong*. Separation of Acetylferrocene from synthetic mixtures by countercurrent chromatography. Journal of Liquid Chromatography & Related Technologies, 2022, 45(5-8), 94-99.  DOI:10.1080/10826076.2022.2143798.

8. Ping Xu, Xiang Wang, Tingting Lin, Qingsong Shao, Jianyun Peng, Chu Chu, Shengqiang Tong*.A Strategy for Pinpointing Natural Bioactive Components Using Two-Dimensional Bioassay Profilings Combined with Comprehensive Two-Dimensional Countercurrent Chromatography × High-Performance Liquid Chromatography. Analytical Chemistry, Publication Date:September 8,  2022, 94, 37, 12715–12722. https://doi.org/10.1021/acs.analchem.2c02196.

9. Tingting Lin; Ben Chen; Liqun Fang; Haibo You; Chu Chu; Qingsong Shao; Shengqiang Tong*. Solvent strength of organic phase for two biphasic solvent systems in high speed countercurrent chromatography, Journal of Chromatography A, Available online 14 August 2022, 1680, 463422. . https://doi.org/10.1016/j.chroma.2022.463422

10. Heng-Mian Sun, Ai-Lian Zhang, Hong-Lei Bao, ChuChu*, Sheng-Qiang Tong*, In Silico Screening of Off-line Comprehensive Two-Dimensional Counter-current Chromatography with Liquid Chromatography for Four Saponins Isolation. Journal of Separation Science, 2022, 45:3909–3918. http://doi.org/10.1002/jssc.202200395

11. Ben Chen, Tingting Lin, Haibo You, Liqun Fang, ChuChu, Jintao Yang*, Shengqiang Tong*. Preparation of Sulfobutylether-β-cyclodextrin Bonded Fe3O4/SiO2 Core-Shell Nanoparticles and its Application in Enantioselective Liquid-Liquid Extraction. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 652: 129861. https://doi.org/10.1016/j.colsurfa.2022.129861

12. Haiping Xiang, Ping Xu, Huiyun Qiu, Weiyi Wen, Ailian Zhang, Shengqiang Tong*. Two-dimensional chromatography in screening of bioactive components from natural products, Phytochemical Analysis,  2022, 33(8), 1161-1176. https://doi.org/10.1002/pca.3168

13. Wenyu Sun, Ben Chen, Haibo You, Liqun Fang, Junqing Qian*, Shengqiang Tong*. Enantioseparation of N-methyl duloxetine, duloxetine and fluoxetine by countercurrent chromatography using anionic β-cyclodextrin as chiral selector, Journal of Separation Science, First published: 22 May 2022,  45(15), 3022-3030.  http://doi.org/10.1002/jssc.202200151

14. Ben Chen, Haibo You, Liqun Fang, Tingting Lin, Ping Xu, ChuChu, Shengqiang Tong*. Enantioseparation of five racemic N-alkyl drugs by reverse phase HPLC using sulfobutylether-β-cyclodextrin as a chiral mobile phase additive, Journal of Separation Science, First published: 24 March 2022,  45(11), 1847-1855. https://doi.org/10.1002/jssc.202200004

15. Tingting Lin, Ping Xu, Ben Chen, Liqun Fang, Haibo You, Shengqiang Tong*. Solvent strength of aqueous phase for two typical biphasic solvent systems in high-speed countercurrent chromatography, Journal of Chromatography A, 2022, 1663, 462767.https://doi.org/10.1016/j.chroma.2021.462767

16. Honglei Bao, Wenyu Sun, Hengmian Sun, Yang Jin, Xingchu Gong, ChuChu, Shengqiang Tong*. Liquid chromatographic study of two structural isomeric pentacyclic triterpenes on reversed-phase stationary phase with hydroxypropyl-β-cyclodextrin as mobile phase additive, Journal of Pharmaceutical and Biomedical Analysis, 2022, 207: 114420. https://doi.org/10.1016/j.jpba.2021.114420

17.Hengmian Sun, Li-Juan Ma, Jian-Bo Wan*, Shengqiang Tong*. Preparative separation of gypenoside XVII, ginsenoside Rd2, and notoginsenosides Fe and Fd from Panax notoginseng leaves by countercurrent chromatography and orthogonality evaluation for their separation. Journal of separation science,  2021, 44(15):2996-3003. https://doi.org/10.1002/jssc.202100078 

18.Honglei Bao, Wenyu Sun, Yang Jin, Chaoyue Wang, Xiang Wang, Hengmian Sun, Chu Chu*, Shengqiang Tong*,Preparative separation of structural isomeric pentacyclic triterpenes from Eriobotrya japonica (Thunb.) leaves by high speed countercurrent chromatography with hydroxypropyl-β-cyclodextrin as additive, Journal of Chromatography A, 1646 (2021) 462066.  https://doi.org/10.1016/j.chroma.2021.462066 

19.Shanshan Zhao, Xiang Wang, Wenyu Sun, Xingchu Gong, Jizhong Yan, Shengqiang Tong*. Application of Liquid-liquid chromatography as a sample pretreatment method for quantitative analysis of synephrine in Fructus Aurantii Immaturus. Journal of Liquid Chromatography & Related Technologies,2021, 44 (3-4): 189-196. https://doi.org/10.1080/10826076.2021.1874981 

20.Yang Jin, Honglei Bao, Wenyu Sun, Shengqiang Tong*. Enantioseparation of three constitutional isomeric 2-(methylphenyl)propanoic acids by countercurrent chromatography, Journal of Chromatography A, 2021, 1637: 461804. https://doi.org/10.1016/j.chroma.2020.461804 

21.Wenyu Sun, Honglei Bao, Junqing Qian*, Shengqiang Tong*. Enantioseparation of ondansetron by countercurrent chromatography using sulfobutyl ether-β-cyclodextrin as chiral selector, Journal of separation science, 2021, 44: 922–930. https://doi.org/10.1002/jssc.202001118 

22.Yang Jin, Honglei Bao, Wenyu Sun, Hengmian Sun, Shanshan Zhao, Xiang Wang, Shengqiang Tong*. Enantioseparation of 2-(4-chlorophenyl)succinic acid by countercurrent chromatography and investigation of injection volume on resolution, Journal of separation science, 2021，44: 752–758. https://doi.org/10.1002/jssc.202000860 

23.Xiang Wang, Shanshan Zhao, Chaoyue Wang, Wei Du, Hengmian Sun, Wenyu Sun, Yang Jin, Guanglei Zuo, Shengqiang Tong*. Orthogonality in the selection of biphasic solvent systems for off-line two-dimensionalcountercurrent chromatography from Polygonum cuspidatum Sieb. et Zucc. Journal of Chromatography A, 2020, 1634: 461666. https://doi.org/10.1016/j.chroma.2020.461666 

24.Yang Jin, Wenyu Sun, Huawei Lv, Shengqiang Tong*. Spectral study on inclusion interaction and enantiorecognition of 2-aryl carboxylic acids with hydroxypropyl-β-cyclodextrin, Chirality, 2020, 32, 1257–1263. http://dx.doi.org/10.1002/chir.23276 

25.Chaoyue Wang, Guanglei Zuo, Xiang Wang, Hyun Yong Kim, Shanshan Zhao,Wenyu Sun, Shengqiang Tong*, and Soon Sung Lim*. Retention mechanism of pH-peak-focusing in countercurrent chromatographic separation of baicalin and wogonoside from Scutellaria baicalensis Georgi. Journal of Separation Science, 2020, 43(19), 3806-3815. https://doi.org/10.1002/jssc.202000455 

26.Xiang Wang, Guang-Lei Zuo, Chao-Yue Wang, Hyun Yong Kim, Soon Sung Lim and Sheng-Qiang Tong*. An Off-Line DPPH-GC-MS Coupling Countercurrent Chromatography Method for Screening, Identification, and Separation of Antioxidant Compounds in Essential Oil, Antioxidants 2020, 9, 702. doi:10.3390/antiox9080702 

27.Chaoyue Wang, Xiang Wang, Shanshan Zhao, Guanglei Zuo, Min Xu, Shengqiang Tong, Liquid chromatographic and liquid-liquid chromatographic separation of structural isomeric oleanolic acid and ursolic acid using hydroxypropyl-β-cyclodextrin as additive, Journal of Chromatography A, 2020, 1625, 461332. https://doi.org/10.1016/j.chroma.2020.461332 

28.Shengqiang Tong, Liquid-liquid chromatography in enantioseparations, Journal of Chromatography A, 2020, 1626, 461345. https://doi.org/10.1016/j.chroma.2020.461345 

29.Shanshan Zhao, Chaoyue Wang, Xiang Wang, Yang Jin, Wenyu Sun, Xingchu Gong, Shengqiang Tong. Liquid-liquid chromatography in sample pretreatment for quantitative analysis of trace component in traditional Chinese medicines by conventional liquid chromatography, Journal of Chromatography A, 2020, 1619, 460917. https://doi.org/10.1016/j.chroma.2020.460917 

30.Wenyu Sun, Yang Jin, Chaoyue Wang, Shanshan Zhao, Xiang Wang, Meng Luo, Jizhong Yan, Shengqiang Tong. Stereoselective separation of isomeric sertraline with analytical countercurrent chromatography, Journal of Chromatography A 2020, 1617, 460834. https://doi.org/10.1016/j.chroma.2019.460834 

31.Huawei Lv, Mengxia Lu, Shengqiang Tong*. Chromatographic study of four sesquiterpenoids in volatile oil of Curcumae Rhizoma on reverse phase stationary phase with methyl-β-cyclodextrin as mobile additive, Journal of Liquid Chromatography & Related Technologies, 2020, 43(13-14), 508-515. https://doi.org/10.1080/10826076.2020.1742737 

32.Xujun Qiu, Wenyu Sun, Chaoyue Wang, Jizhong Yan, Shengqiang Tong*. Enantioseparation of acetyltropic acid by countercurrent chromatography with sulfobutyl ether-β-cyclodextrin as chiral selector, Journal of separation science, 2020, 43:681–688. https://doi.org/10.1002/jssc.201900730.

33.Xiang Wang, Shanshan Zhao, Chaoyue Wang, Wenyu Sun, Yang Jin, Xingchu Gong, Shengqiang Tong*. Off-line comprehensive two-dimensional reversed-phase countercurrent chromatography with high-performance liquid chromatography: Orthogonality in separation of Polygonum cuspidatum Sieb. et Zucc, Journal of separation science, 2020, 43:561–568. https://doi.org/10.1002/jssc.201900877.

Screening of natural bioactive components

Chinese medicine quality control based on bioactivity

Chiral chromatographic separations

Enantioselective liquid-liquid extractions

Comprehensive two-dimensional chromatography