Work Experience 

Aug11, 2016~Sep 15, 2017 Visiting associate Professor, School of Medicine, Yale University

Oct 30, 2009~             Associate Professor, Zhejiang University of Technology

Aug 31, 2006~             Lecturer, Zhejiang University of Technology

Education

June, 2006: Ph. D. in Biomedical Engineering. Zhejiang University, Hangzhou, China.

July, 2003: Master Degree in Pharmaceutical Sciences. Huazhong University of Science and Technology, Wuhan, China.

July, 2000: B.S. in Pharmaceutical Sciences. Tongji Medical University, Wuhan, China.

Academic Members

Member of the Council of Zhejiang Pharmacology Society

Member of Chinese Pharmacological Society

Member of Drug Safety Evaluation & Study Special Committee of Zhejiang Society of Toxicology

Academic Editor for PLOS ONE; Guest Editor for Molecules;

Reviewer for Trends in Cell Biology, Journal of Pharmacy and Pharmacology, Food & Function, Current Drug Targets, ASSAY and Drug Development Technologies, Biomolecules, Journal of Functional Foods,Mini-Reviews in Medicinal Chemistry, etc.

Research Interests

My research interests focus on the following (1) Mechanisms, biomarker, drug targets of the Metabolic disorders and cancer, and photogenetic control and its application in life metabolism; (2) Spatiotemporal network regulation of glucose and lipid metabolism, GLUT4 vesicle trafficking; (3) Screening of active ingredients from Traditional Chinese Medicine against the Metabolic Syndrome including obesity, diabetes, NAFLD, and sarcopenia.

Publications

2023

1.      Li H*, Fu G, Zhong W. Natural quinazolinones: From a treasure house to promising anticancer leads. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114915. doi: 10.1016/j.ejmech.2022.114915.

2.      Yao Y^#, Li H^#, Wang X, Sun Y, Zhao X, Zha W, Zhou J, Toomre D, Fu J, Xu Y. Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells. Genes Dis. 2023 Feb 3;10(5):1787-1790. doi: 10.1016/j.gendis.2023.01.007.

3.      Li H*, Gong W, Sun W, Yao Y, Han Y*. Role of VPS39, a key tethering protein for endolysosomal trafficking and mitochondria-lysosome crosstalk, in health and disease. J Cell Biochem. 2023 Mar 16. doi: 10.1002/jcb.30396.

4.      Ke S, Hu Q, Zhu G, Li L, Sun X, Cheng H, Li L, Yao Y, Li H*. Remodeling of white adipose tissue microenvironment against obesity by phytochemicals. Phytother Res. 2023 Feb 14. doi: 10.1002/ptr.7758.

5.      Hong W, Lou B, Gao Y, Zhao H, Ying S, Yang S, Li H, Yang Q, Yang G. Tumor microenvironment responded naturally extracted FOF1-ATPase loaded chromatophores for antitumor therapy. Int J Biol Macromol. 2023 Mar 1;230:123127. doi: 10.1016/j.ijbiomac.2022.123127.

2022

1.      Li L, Sun Y, Zha W, Li L, Li H*. Novel insights into the N6-methyladenosine RNA modification and phytochemical intervention in lipid metabolism. Toxicol Appl Pharmacol. 2022 Nov 24;457:116323. doi: 10.1016/j.taap.2022.116323.

2.      Guo Y, Li L, Yao Y, Li H*. Regeneration of Pancreatic β-Cells for Diabetes Therapeutics by Natural DYRK1A Inhibitors. Metabolites. 2022 Dec 29;13(1):51. doi: 10.3390/metabo13010051.

3.      Zha W, Sun Y, Gong W, Li L, Kim W, Li H*. Ginseng and ginsenosides: Therapeutic potential for sarcopenia. Biomed Pharmacother. 2022 Dec;156:113876. doi: 10.1016/j.biopha.2022.113876.

4.      Li L, Zhu G, Fu G, Zha W, Li H*. Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation. Int J Mol Sci. 2022 Sep 9;23(18):10465. doi: 10.3390/ijms231810465.

5.      Zheng W, Li L, Li H*. Phytochemicals modulate pancreatic islet β cell function through glucagon-like peptide-1-related mechanisms. Biochem Pharmacol. 2022 Mar;197:114817. doi: 10.1016/j.bcp.2021.114817.

2021

1.      Zhang S, Li L, Li H*. Role of ectopic olfactory receptors in glucose and lipid metabolism. Br J Pharmacol. 2021 Aug 19. doi: 10.1111/bph.15666. PMID: 34411276.

2.   Hanbing Li*, Can Wang, Linghuan Li, Lingqiao Li. Skeletal muscle non-shivering thermogenesis as an attractive strategy to combat obesity.Life Sci 2021 Jan 12;269:119024.doi: 10.1016/j.lfs.2021.119024

3.      Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, López-Giráldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, González Zapata S, Dann P, Brown SN, Hirabara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS. Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Nat Metab. 2021 Mar;3(3):378-393. doi: 10.1038/s42255-021-00359-x.

2020

1.      Li LH, Zheng WF, Wang C, Qi JM, Li HB*. Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.Evidence-Based Complementary and Alternative Medicine 2020:7826874.DOI: 10.1155/2020/7826874

2.      Hanbing Li, Ping Shentu, Mei Xiao, Xuqin Zhao, Jiannan Fan, Xuechun Liu, Yinyan Lin, Lei Wang, Hong Li, Xiaogang Guo, Olof Idevall-Hagren, Yingke Xu*. Dual Function of PI(4,5)P 2 in Insulin-Regulated Exocytic Trafficking of GLUT4 in Adipocytes.Journal of Molecular Biology 2020;432(16):4341-4357. DOI: 10.1016/j.jmb.2020.06.019

3.      Huawei Lv, Yuxia Li, Mengdi Zhu, Meng Luo, Jiameng Qi, Zhefeng Yu, Hongjian Zhang, Yuanqiang Guo, Shengqiang Tong, Hanbing Li*, Jizhong Yan*. A cyclic peptide and two pairs of norlignan lignanoside epimers from Selaginella pulvinata. Fitoterapia 2020,143:104562. DOI: 10.1016/j.fitote.2020.104562.

4.      Hua-Wei Lv, Yu-Xia Li , Meng Luo, Jia-Meng Qi, Ze-Fei Fu, Hong-Jian Zhang, Yuan-Qiang Guo, Chu Chu, Hanbing Li*, Jizhong Yan*. Two new nor-lignans from Selaginella pulvinata (Hook. & Grev.) Maxim and their antihyperglycemic activities. Natural Product Research: 2020:1-8.

5.      Yao Y, Wang X, Li H, Fan J, Qian X, Li H, Xu Y*. Phospholipase D as a key modulator of cancer progression.Biological Reviews.Biol Rev Camb Philos Soc. 2020 Aug;95(4):911-935.

2019

1.      Li H, Qi J, Li H*. Phytochemicals as potential candidates to combat obesity via adipose non-shivering thermogenesis. Pharmacol Res. 2019 Aug 8;147:104393.

2.      Mo Z, Li L, Yu H, Wu Y, Li H*. Coumarins ameliorate diabetogenic action of dexamethasone via Akt activation and AMPK signaling in skeletal muscle. J Pharmacol Sci. 2019 Jan 23. doi: 10.1016/j.jphs.2019.01.001.

3.      Lee G, Kim W, Kim W, Li HB. Modernization of Traditional Oriental Medicine: New Dosage Forms and Medical Instruments. Evid Based Complement Alternat Med. 2018 Jun 10;2018:6960125. doi: 10.1155/2018/6960125 (Editorial).

4.      Li L, Qi J, Li H*. Natural Products Modulating Autophagy Pathway against the Pathogenesis of Diabetes Mellitus. Curr Drug Targets. 2019;20(1):96-110. doi: 10.2174/1389450119666180726115805.

5.      Li Hanbing*, Zhao Xuqin, Wang Xinyi, Qi Jiameng, Wang can, Yao Yuanfa. Research progress on anti-tumor mechanism of metformin independent of adenylate activated protein kinase pathway. Chinese Journal of pharmacology and toxicology. 2019; (33) 7:525-534

2018

1.      Yuanfa Yao, Xuqin Zhao, Jingxia Xin, Yingqi Wu, Hanbing Li*. Coumarins improved type 2 diabetes induced by high-fat diet and streptozotocin in mice via antioxidation. Can J Physiol Pharmacol. 2018 Apr 11. doi: 10.1139/cjpp-2017-0612.

2.      Habtemichael EN, Li DT, Alcázar-Román A, Westergaard XO, Li M, Petersen MC, Li H, DeVries SG, Li E, Julca-Zevallos O, Wolenski JS, Bogan JS*. Usp25m protease regulates ubiquitin-like processing of TUG proteins to control GLUT4 glucose transporter translocation in adipocytes. J Biol Chem. 2018 Jul 6;293(27):10466-10486.

3.      Guo F, Huang D, Zhang W, Yan Q, Yang Q, Yang Y, Li H, Yun J, Hong W, Yang G*. Star-shaped polyester-based elastomers as an implantable delivery system for insulin: Development, pharmacokinetics, pharmacodynamics, and biocompatibility. Mater Sci Eng C Mater Biol Appl. 2018;84:180-187.

4.      Mei Xiao, Xuqin Zhao, Yingke Xu, Hanbing Li*. Regulatory role of phosphatidylinositol signaling in GLUT4 vesicle transport. Chinese Journal of cell biology, 2018.1, 40(1): 139~145.

2017

1.      Hanbing Li*, Yuanfa Yao, Linghuan Li. Coumarins as potential antidiabetic agents. J Pharm Pharmacol. 2017;69(10):1253-1264.

2.      Hanbing Li, Liting Ou, Jiannan Fan, Mei Xiao, Cuifang Kuang, Xu Liu, Yonghong Sun, Yingke Xu*. Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts. FEBS Lett. 2017 Feb;591(3):491-499.

2016 and before

1.      Linghuan Li, Yuanfa Yao, Hanbing Li*. Research Progress on the effect and mechanism of PM2.5 on insulin resistance. Chinese Journal of pharmacology and Toxicology. 2016.11, 30(11): 1230~1236.

2.      Liting Ou, Yinge Xu, Hanbing Li*. Research progress of Rab protein regulating glucose transporter 4 transport mechanism. Chinese Journal of pharmacology and Toxicology 2016.7, 30(7): 770~776.

3.      Hanbing Li*, Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition. Brazilian Journal of Medical and Biological Research, 2015;48(5): 440-446.

4.      Hanbing Li*, Yunxue Pan, Jing Nie. Astragaloside IV improved insulin resistance in L6 myotubes induced by high glucose and insulin. Inernational Conference on Remote Sensing, Enviroment and Transportantion Engineering (RSETE), 2011,7515-7518. (ISBN: 978-1-4244-9172-8; doi: 10.1109/RSETE.2011.5966083)

5.      Han-Bing Li*, Ya-Kun Ge, Xiao-Xiang Zheng, Le Zhang. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. European Journal of Pharmacology 2008,588:165-169.

6.      Han-Bing Li, Ya-Kun Ge, Le Zhang, Xiao-Xiang Zheng*. Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. Life Sciences 2006,79:1186-1193.

7.      Han-Bing Li, Tong-Le Deng, Qing-Nan Zhang, Xiao-Xiang Zheng*. Label-free and Dynamic Monitoring of Endothelial Barrier Function on Microelectronic Cell Sensor Arrays. Chinese Journal of Cell Biology 2007,29:91-96 (ISSN: 1674-7666).

8.      Xiaoxiang Zheng, Yun Zhang, Wei Yuan, Xiaolong Li, Hanbing Li, Weimin Yan. A series of methods For screening and evaluating potential anti-cardiovascular drugs from traditional Chinese herbs, Recent progress in medicinal plants, volume 25(Chemistry and medicinal value), U.S.A. Studium Press LLC, 2009:185-201.