居述云，朝晖特聘研究员（运河青年学者），博士生导师。

浙江大学工学博士(导师：吴坚平教授），曾在浙江大学和美国加州大学圣巴巴拉分校开展博士后研究工作(合作导师：杨立荣教授、Yang Yang教授）。2024年加入浙江工业大学药学院，主要从事生命健康领域教学与科研工作，研究聚焦生物催化反应设计、酶的定向改造、化学-酶或多酶级联催化人工合成途径的组装与调控等方向，相关研究成果已发表于Nature Chemistry、Nature Communications、ACS Catalysis、Green Chemistry等期刊，累计获授权国家发明专利11件，美国发明专利1件，参与编写生物催化专著2部。主持国家自然科学基金面上项目、浙江省自然科学基金探索项目、浙江省“尖兵”研发攻关计划项目子课题；作为项目骨干参与国家重点研发计划绿色生物制造专项。

The accelerating development of biocatalysis

学术论文：

Shuyun Ju^#, Dian Li^#, Binh Khanh Mai, Xin Liu, Alec Vallota-Eastman, Jianping Wu, David L. Valentine, Peng Liu^* and Yang Yang^*. Stereodivergent photobiocatalytic radical cyclisation through the repurposing and directed evolution of fatty acid photodecarboxylases. Nature Chemistry, 2024, 16, 1339–1347.

       Featured in Chemistry World: Light-driven enzyme engineered and repurposed to catalyse unnatural reaction.

    Highlighted by Benjamin List and Margareta M. Poje in Synfacts, 2024, 20 (7), 0746: Stereodivergent radical cyclizations  enabled by  directed evolution of fatty acid photodecarboxylases.

Shuyun Ju^#, Kaylee P. Kuzelka^#, Rui Guo, Benjamin Krohn-Hansen, Jianping Wu, Satish K. Nair^*, Yang Yang^*. A biocatalytic platform for asymmetric alkylation of α-keto acids by mining and engineering of methyltransferases. Nature Communications, 2023, 14(1), 5704.

Shuyun Ju, Xiaoshu Zhou, Huanhuan Jin, Yang Yang, Lirong Yang, Jianping Wu^*. Stereoselective oxidative C3-N bond dehydrogenation and aromatization of 1-carboxyl substituted tetrahydroisoquinolines employing pipecolate oxidase. Green Synthesis and Catalysis, 2026, 7, 182–187.

Huanhuan Jin, Ziyuan Wang, Zhongji Pu, Haoran Yu, Yuhuan Chen, Xiaoshu Zhou, Lirong Yang, Shuyun Ju^*, Jianping Wu^*. Enantiodivergent kinetic resolution of 4-substituted 1,2,3,4-tetrahydroquinolines employing amine oxidase. International Journal of Biological Macromolecules, 2024, 269, 132102.

Huanhuan Jin, Shuyun Ju^*, Haoran Yu, Lirong Yang, Wenlong Zheng, Jianping Wu^*. An efficient biocatalytic oxidative dehydroaromatization approach for the construction of quinolines enabled by monoamine oxidase with molecular oxygen. Green Chemistry, 2023, 25(13), 5296–5303.

居述云, 吴坚平, 杨立荣^*. D-氨基酸氧化酶的分子改造及应用研究进展. 化工进展, 2021, 40(3), 1215–1225. [特约评述]

Tianxin Liang, Jun Sun, Shuyun Ju^*, Shenyi Su, Lirong Yang, Jianping Wu^*. Construction of T7-like expression system in Pseudomonas putida KT2440 to enhance the heterologous expression level. Frontiers in Chemistry, 2021, 9, 664967.

Guosi Li, Jiazhang Lian, Hailong Xue, Yiqi Jiang, Shuyun Ju, Mianbin Wu, Jianping Lin^*, Lirong Yang. Biocascade synthesis of L-tyrosine derivatives by coupling a thermophilic tyrosine phenol lyase and L-lactate oxidase. European Journal of Organic Chemistry, 2020, 8, 1050–1054.

Shuyun Ju, Mingxin Qian, Jing Li, Gang Xu, Lirong Yang, Jianping Wu^*. A biocatalytic redox cascade approach for one-pot deracemization of carboxyl-substituted tetrahydroisoquinolines by stereoinversion. Green Chemistry, 2019, 21(21), 5579–5585.

Shuyun Ju, Mingxin Qian, Gang Xu, Lirong Yang, Jianping Wu^*. Chemoenzymatic approach to (S)-1,2,3,4-tetrahydroisoquinoline carboxylic acids employing D-amino acid oxidase. Advanced Synthesis & Catalysis, 2019, 361(13), 3191–3199.

    Featured in Applied Biocatalysis: The Chemist's Enzyme Toolbox, 2020, Chapter 12, Chemo-Enzymatic Cascade: chemo-enzymatic synthesis of (S)-1,2,3,4-tetrahydroisoquinoline carboxylic acids.

An Huang, Xianheng Song, Linlin Song, Shuangshuang Pan, Jiaxin Tian, Pengfei Wang, Shuyun Ju, Yajun Wang^*. Reshaping the substrate-binding pocket of ene-reductase for enhanced and inverted stereoselectivity: a concise access to the stereocomplementary chiral GABA derivatives. ACS Catalysis, 2025, 15, 1961–1972.

Jiaqi Zhu, Jianeng Xu, Xinru Bian, Peng Cheng, Zhe Dou, Wenting Dai, Shuyun Ju, Yajun Wang*. Enhancing the stability and activity of enzymes through layer-by-layer immobilization with nanocomposite hydrogel. Biochemical Engineering Journal, 2025, 215, 109604.

Lili Yao, Bin Xue, Yuanfan Ye, Zhixiu Wang, Yangyang Li, Beifengchu Zheng,  Shuyun Ju, Yajun Wang^*. Structure-guided engineering of carbonyl reductase LbCR to simultaneously enhance catalytic activity and thermostability toward bulky ketones. Journal of Agricultural and Food Chemistry, 2025, 73, 10470–10481.

An Huang, Yanjun Wan, Xianheng Song, Wenmei Feng, Shuyun Ju, and Yajun Wang^*. Combining Residue Substitution and Deletion Engineering Enhances the Substrate Acceptance of Ene-Reductase for Highly Enantioselective Synthesis of β‑Cyano Ester Scaffolds. ACS Sustainable Chemistry & Engineering, 2026, 14, 2965–2979.

Zhixiu Wang^#, Bin Xue^#, Xiang Wang, Jun Tang, Luying Gu, Yuan Yuan, Lili Yao, Shuyun Ju^*, Guiyun Zhao^*, and Yajun Wang. Structure-guided engineering of a sucrose phosphorylase from Clostridium beijerinckii for efficient α‑arbutin production. ACS Sustainable Chemistry & Engineering, 2026, 14, 9608−9619.

Muhammad Shafiq, Liaqat Zeb, Xiang Wang, Chen Wang, Yi He, Huasong Luo, Muhammad Ayaz, Bin Xue, Yanjun Wan, Wen Zhang, Xianheng Song, Yuan Yuan, Shuyun Ju^*, Yajun Wang. AI-Assisted rational enzyme engineering: advancing biocatalysis for industrial applications. Catalysis Reviews, 2026, doi.org/10.1080/01614940.2026.2733243.

J. Agric. Food Chem.2025, 73, 10470−10481J. Agric. Food Chem.2025, 73, 10470−10481Structure-Guided Engineering of Carbonyl ReductaseLbCR to
Simultaneously Enhance Catalytic Activity and Thermostability
toward Bulky KetonesStructure-Guided Engineering of Carbonyl ReductaseLbCR to
Simultaneously Enhance Catalytic Activity and Thermostability
toward Bulky Ketones

主持项目基金：

2026.01-2027.12               浙江省自然科学基金探索项目（面上项目）                                   

2026.01-2029.12               国家自然科学基金面上项目

2026.01-2029.12               大型仪器设备开放基金项目                                      

2025.01-2026.12               浙江省“尖兵领雁+X”科技计划项目子课题                       

2024.07-2029.07               浙江工业大学科研启动基金                                     

教学：

本科生课程：生物化学、生物化学实验、酶工程

研究生课程：高等生物化学、工业酶构建技术与应用、酶学与酶工程、药物生物合成技术进展

教材编写：

生物催化剂工程原理及应用（主编：郁惠蕾，许建和），化学工业出版社，2025.

Applied Biocatalysis: The Chemist's Enzyme Toolbox (Editors: John Whittall & Peter W. Sutton), WILEY Press, 2021.

招生：课题组有硕士（100700、105500、086000）、博士（100700、086000）招生名额，欢迎报考。

博士后招聘：

一、薪资待遇

1. 工资及福利待遇按浙江工业大学博士后相关规定执行，浙工大年薪+合作导师津贴；

2. 学校提供博士后公寓（优惠价格租住）；

3. 为博士后提供良好的实验与科研条件，以及参加国内外高水平学术会议的机会；

4. 业绩优秀者出站后可申请留校工作。

二、招聘条件及要求

1. 近三年内获得博士学位或入职前可以获得博士学位，以第一作者发表过文章。

2. 对科研工作有浓厚的兴趣，有较强科研素养和英文读写能力；

3. 具备较强的独立科研能力、良好的敬业精神和团队合作精神；

4. 专业方向要求：

（1）有机合成化学；

（2）生物催化。

三、应聘材料

1. 详细个人简历一份（教育经历、工作经历、研究经历、发表论文、荣誉奖励等）。

2. 未来工作设想。

3. 至少1篇代表性论文。

四、联系方式

联系人：居述云   个人主页：https://homepage.zjut.edu.cn/jsy1/

E-mail：shuyunju@zjut.edu.cn 注明“博士后申请+姓名”