姜灵

教育经历

2010/09-2014/06    浙江大学   生物化工   博士

Ø  研究方向：水解酶催化多功能性的研究  于洪巍教授     

2007/09-2010/06  浙江工业大学   药物化学   硕士

Ø  研究方向：BTC在药物合成中的应用  苏为科教授/陈志卫副教授     

2003/09-2007/06  浙江工业大学   制药工程（化学制药方向）  学士

工作经历

2019/02-至今    浙江工业大学绿色制药协同创新中心   助理研究员

Ø   研究方向：化学-酶法耦合技术在药物（中间体）绿色合成中的应用   

2014/11-2018/12  浙江工业大学化学工程学院   博士后

Ø   研究方向：生物催化技术在维生素及降压药绿色合成中的应用   苏为科教授

1. 酯酶催化碳-碳成键的分子机制、理性改造及其应用研究，国家自然科学基金，主持；

2. 酯酶催化不对称Aldol反应的基础研究，中国博士后科学基金，主持；

3. 脂肪酶的定向固定化及其催化新型氮(氧)杂环化合物合成的研究，浙江省博士后科研项目择优资助，主持

4. 甾体工业生产菌底物跨膜系统改造与侧链降解强化研究，国家重点研发计划子课题，参与 

5. 固定化酶法合成L-瓜氨酸工艺开发, 校企合作，主持

1. Ling Jiang, Hai-Ling Yang, Qiong Xiao, Qian-Qian Huang, Li-Dan Ye, Xiao-He Chu*, Efficient synthesis of (S)-aromatic epoxides by coupling mechanochemical synthesis and biocatalysis technology, ACS Sustainable Chemistry & Engineering, 2024, 12(37), 13774-13782.

2. Ling Jiang, Si-Yu Yan, Jing-Wen Dong, Li-Dan Ye, Yue Cheng, Xiao-He Chu*, Catalyst-free one-pot three-component rapid synthesis of polysubstituted pyrroles by liquid-assisted grinding, Journal of Heterocyclic Chemistry, 2022, 59(9), 1561-1572.

3. Ling Jiang, Qing-Qing Lu, Qian-Qian Tang, Yue Cheng, Xiao-He Chu*, L-cysteine catalyzed one-pot synthesis of bicyclic d-lactones under ball-milling conditions, Heterocycles, 2022, 104(5), 934-944.

4. Ling Jiang, Qing-Qing Lu, Jing-Wen Dong, Xiao-He Chu*, Mechano-biocatalytic rapid synthesis of 2-amino-3-cyano-4H-pyran derivatives, Heterocycles, 2022, 104(4), 723-738.

5. Ling Jiang, Qing-Qing Lu, Qian-Qian Huang, Yue Cheng, Xiao-He Chu*, One-pot two-step mechanochemical synthesis of arylsulfonyl 4H-pyrans, Journal of Sulfur Chemistry, 2022, 43(3), 304-313.

6. Ling Jiang, Li-Dan Ye, Jia-Li Gu, Wei-Ke Su*, Wen-Ting Ye, Mechanochemical enzymatic synthesis of 1,4-dihydropyridine calcium antagonists and derivatives, Journal of Chemical Technology & Biotechnology, 2019, 94(8),  2555-2560.

7. Ling Jiang, Wen-Ting Ye, Wei-Ke Su*, One-pot Multicomponent synthesis of highly functionalized 1,4-dihydropyridines using porcine pancreatic lipase, Chemical Research in Chinese Universities, 2019, 35(2), 235-238.

8. Ling Jiang, Wen-Ting Ye, Wei-Ke Su, Chuan-Ming Yu*, Application of enzymatic promiscuity in pharmaceutical synthesis: papain-catalyzed one-pot synthesis of 1,4-dihydropyridine calcium channel antagonists and derivatives, Chemical Research in Chinese Universities, 2019, 35(1), 21-25.

9. Ling Jiang, Hong-Wei Yu*, Enzymatic promiscuity: amano lipase AS-catalysed synthesis of naphthopyran derivatives in anhydrous media, Chemical Research in Chinese Universities, 2014, 30(3), 396-399.

10. Ling Jiang, Hong-Wei Yu*, Enzymatic promiscuity: Escherichia coli BioH esterase-catalysed aldol reaction and knoevenagel reaction, Chemical Research in Chinese Universities, 2014, 30(2), 289-292.

11. Ling Jiang, Bo Wang, Rong-Rong Li, Sa Shen, Hong-Wei Yu, Li-Dan Ye*, Amano lipase DF-catalyzed efficient synthesis of 2,2'-arylmethylene dicyclohexane-1,3-dione derivatives in anhydrous media, Chinese Chemical Letters, 2014, 25(8), 1190-1192.

12. Ling jiang, Hong-Wei Yu*, An example of enzymatic promiscuity: the Baylis-Hillman reaction catalyzed by a biotin esterase (BioH) from Escherichia coli, Biotechnology Letters, 2014, 36(1), 99-103.

13. Ling Jiang, Bo Wang, Rong-Rong Li, Sa Shen, Hong-Wei Yu, Li-Dan Ye*, Catalytic promiscuity of Escherichia coli BioH esterase: Application in the synthesis of 3,4-dihydropyran derivatives, Process Biochemistry, 2014, 49(7), 1135-1138.